It's not clear why this happens, but it's responsible for 70% to 90% of cases in the UK. Why it happensĪddison's disease is usually the result of a problem with the immune system, which causes it to attack the outer layer of the adrenal gland (the adrenal cortex), disrupting the production of the steroid hormones aldosterone and cortisol. You may also develop small areas of darkened skin, or darkened lips or gums.Īlthough these symptoms are not always caused by Addison's disease, you should see a GP so they can be investigated.

Over time, these problems may become more severe and you may experience further symptoms, such as dizziness, fainting, cramps and exhaustion. loss of appetite and unintentional weight loss.

Symptoms of Addison's diseaseĮarly-stage symptoms of Addison's disease are similar to other more common health conditions, such as clinical depression or flu. It can affect people of any age, although it's most common between the ages of 30 and 50. It's also more common in women than men. The adrenal gland is damaged in Addison's disease, so it does not produce enough cortisol or aldosterone.Ībout 9,000 people in the UK have Addison's disease, with over 300 new cases diagnosed each year. They produce 2 essential hormones: cortisol and aldosterone. The adrenal glands are 2 small glands that sit on top of the kidneys. Addison's disease, also known as primary adrenal insufficiency or hypoadrenalism, is a rare disorder of the adrenal glands.

Signs of an overactive adrenal gland